Webber fat burner 66 volum

Review of the biotechnologies and tests used for precancerous cervical lesions diagnosis Ruxandra Viorica Stanculescu, Elvira Bratila, Vasilica Bausic, Teodora Camelia Vladescu, Florina Vasilescu, Alexandra Bausic, Costin Berceanu This paper draws on the author s extensive experience in the clinical research focused on the implementation of the new biotechnologies able to identify precancerous cervical lesions and is intended to be a systematic approach to new achievements.

The goal of this review is to provide updated information concerning the significance of each biotechnology used in clinical medicine to screen women for cervical cancer or to allow a pertinent discrimination between spontaneous remission lesions and progressive lesions.

The data is arranged according to the most widely used biotechnologies and the worldwide recommendations of specialized guidelines. Angiogenesis versus arteriogenesis Anna Rizzi, Vincenzo Benagiano, Domenico Ribatti In the webber fat burner 66 volum system, angiogenesis and arteriogenesis play a unique yet equally important role in both health and disease. Angiogenesis, the formation of new blood vessels from a preexisting vascular bed, occurs naturally during wound healing, the female menstrual cycle and pregnancy.

It plays a critical role in tissue growth and repair, and is a highly controlled process that is dependent on an intricate balance of both pro-angiogenic to stimulate and anti-angiogenic to negatively regulate the phenomenon factors.

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Otherwise, the term arteriogenesis refers to anatomic transformation of preexisting arterioles with increasing lumen area and wall thickness, due to a thick muscular layer and purchasing of visco-elastic and vasomotor capacities. Arteriogenesis differs from angiogenesis in several aspects, the most important being the dependence of angiogenesis on hypoxia and the dependence of arteriogenesis on inflammation.

The expression of growth factors and the cooperation of surrounding and infiltrating cells seem to be essential in orchestrating the complex processes during arteriogenesis. Triple positive breast cancer - a novel category? Breast cancer has been divided in subtypes depending on the presence of hormone receptors HRs for estrogen and progesterone and human epidermal growth factor receptor 2 HER2 gene amplification. We aim to review current evidence on this subtype of BC, from the molecular mechanisms regulating its behavior to the current standard treatment outcome in order to establish whether it qualifies as a new distinct subtype of BC.

Its biology is dominated by the crosstalks between HR pathway and HER2 pathway, which might be responsible for the development of rapid resistance to treatment, because of estrogen receptor up-regulation and alternate regulatory pathways activation when anti-HER2 agents are used.

However, most of the clinical evidence is provided by retrospective trials with multiple potential biases.

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Autophagy is present at a basal level in all mammals and is regulated by some conditions, such as oxidative stress, starvation or hypoxia.

In aged tissues, increased but also decreased expression of autophagy-specific proteins, Beclin 1, LC3, Atg5 and Atg7 has been reported.

Likewise, it could be shown that the lifespan of yeast, nematodes and flies is prolonged by pharmacologically stimulated autophagy using exogenous administered spermidine. Autophagy is potentially implicated in acute lung injury and sepsis, two main causes of morbidity and mortality worldwide. Finally, a quite recent study supports the hypothesis that autophagy might be useful in vascular disease prevention by stimulating cholesterol efflux, which leads to inhibition of necrotic core formation and lipid accumulation.

However, cases of regression have been reported. Recent reviews webber fat burner 66 volum only certain aspects of this disease; therefore, this paper s aim is to cover all the relevant aspects for medical practice, such as clinical, histological and therapeutic details.

BD may affect all regions of the skin and mucosa, but in accordance with the region and etiologic factor, it may embrace different clinical forms, some of them very similar with other skin lesions.

Dermoscopy may prove useful for establishing a clinical diagnosis. Several patterns have been encountered and may help distinguishing from other diseases.

When in doubt, puncture biopsy or complete excision may be performed in order to obtain histological data that could define BD. Different morphological aspects of the involved components are described in order to reduce the risk of misdiagnose. In order for the approach to be complete, relevant information about treatment has been presented, underlining the pros and cons of each available therapy. A systematic review of the possible carcinogenic role of the aristolochic acid Tivadar Bara Jr.

AA is also shown to be involved in the genesis of the upper urinary tract urothelial carcinoma UTUC and some other cancers, but its tumorigenic role is far to be understood. We performed a systematic literature review regarding the involvement of AA in malignant webber fat burner 66 volum and molecular pathways of carcinogenesis.

Twenty representative papers were selected for this review.

These papers reveal that AA exposure increases the risk for UTUC, renal cell carcinoma, hepatocellular carcinoma, gastric and small intestine cancer. The role of AA in lymphomagenesis is also proposed. For further understanding of AA s role in tumorigenesis, the exploration of the AA s molecular signature is necessary.

The ultraviolet influence upon soft eye tissues Sanda Jurja, Malina Coman, Mihaela-Cezarina Hincu The climate changes, which occurred during the last decades, put all living species in front of new challenges. Human biology is no exception to it, all tissues have to face new effects, with unpredictable consequences. Many cancers, mainly affecting the skin, but also many of the eye various structures diseases, have ultraviolet radiation as recognized causative agent.

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The aim of our work is to highlight the changes that can occur after exposure to ultraviolet radiations of webber fat burner 66 volum tissues, including eye structures, by reviewing data from the scientific literature regarding the matter. Responsible for severe diseases, including cancer, ultraviolet negative effects on various soft tissues can be limited by better comprehension. Their knowledge can contribute to improving public health, by finding new preventive methods, which might represent the foundation of effective public health programs.

Role of genetic polymorphism in nutritional supplementation therapy in personalized medicine Nicolae Ovidiu Penes, Bernard Weber, Silviu Dumitru Paun Genetic-guided nutritional supplementation therapy in personalized medicine is the type of treatment that prevents and acts against errors during the copying process of a cell s cum să mi scot grăsimea brațului meu acid DNAmistakes that lead to diversification in the DNA sequence at certain locations, called single nucleotide polymorphisms SNPs.

Positive results are quickly achieved using one of the four types of therapy. These types are: personalized, when individual human genetic variations drive individual treatment, preventive, with a tailored healthcare strategy and therapeutic preventive drugs and vaccines, participatory, when empowered patients make informed choices and take responsibility of their own health and predictive, using a proactive approach to health and medicine.

Three-dimensional organ scanning reveals brain edema reduction in a rat model of stroke treated with an aquaporin 4 inhibitor Elena Silvia Popescu, Ionica Pirici, Raluca Niculina Ciurea, Tudor-Adrian Balseanu, Bogdan Catalin, Claudiu Margaritescu, Laurentiu Mogoanta, Sorin Hostiuc, Daniel Pirici Stroke is one of the most important cause of death and disability, especially when considering the increasing life expectancy worldwide, with ischemic stroke being much more common than hemorrhages.

In the physiopathological chain of ischemic stroke, brain edema is one first element that if attended to might reduce tissue necrosis, penumbra, and increase functional recovery. Aquaporin 4 AQP4 has been found to be the most important water channel in the brain, and its inhibition before inducing focal ischemia in an animal model of stroke proved to alleviate the pathology and improve clinical recovery.

In this study, we have treated a rat model of ischemic stroke with the AQP4 inhibitor TGN after inducing the lesion, and performed for the first time a direct histopathological evaluation of the brain and infarct s volume. Besides utilizing immunohistochemistry targeting the growth-associated protein GAP in order to delineate the webber fat burner 66 volum regions, we have used the Cavalieri s principle of tissue volume measurements starting form seriate sections, and for the first time in neuropathology, we have utilized a high-resolution object scanner to assess global brain volume changes.


Our results showed that TGN clearly reduces infarct volume in TGN treated animals compared to untreated animals, as well as the volume of the brain hemispheres.

Although reduced, the effect was also present in the contralateral hemisphere. Given these data, a more in-depth characterization of the histopathological and molecular changes induced by AQP-4 are needed for considering it as a bona fide treatment option. Prenatal glucocorticoid administration persistently increased the immunohistochemical expression of type-1 metabotropic glutamate receptor and Purkinje cell dendritic growth in the cerebellar cortex of the rat Rodrigo Pascual, Odra Santander, Isabel Cuevas, Martina Valencia Several studies have indicated that abnormal prenatal changes in the circulating glucocorticoids GCsinduced by either maternal stress or exogenous GC administration, significantly alter the development of Purkinje cells PCs.

Among the suggested mechanisms that could mediate this GC-dependent PC susceptibility are changes in the expression of type-1 metabotropic glutamate receptors mGluR1. In the current study, we analyzed whether a single course of prenatally administered betamethasone phosphate BET in pregnant rats increased the immunohistochemical expression of mGluR1 in PCs and decreased PC dendritic growth.

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The data obtained showed that in utero BET exposure resulted in a significant immunohistochemical overexpression of mGluR1 and a significant reduction in Purkinje cell dendritic outgrowth during postnatal life. Large variability of the activity and chronicity indexes within and between histological classes of lupus nephritis Tudor Azoicai, Ioana Madalina Belibou, Ludmila Lozneanu, Simona Eliza Giusca, Elena Cojocaru, Irina-Draga Caruntu Systemic lupus erythematosus SLE is characterized by a multifaceted pathogenesis and a heterogeneous clinical expression.

The present study aimed to reevaluate a series of cases diagnosed as LN, focusing on the histological features in correlation with the level of activity and chronicity. The study group comprised 46 patients. The specimens obtained through percutaneous needle biopsies were processed for light microscopy and immunofluorescence exams.

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In 39 out of the total of 46 The differences in diagnosis were present in seven cases, initially considered as pure membranous glomerulonephritis - class V.

The values of indexes indicated a great variability of LN within the same class. The interobserver agreement for the scoring of activity and chronicity indexes was 0. Our study emphasizes the complex lesion character, which requires an individual and accurate identification, followed by integration in the classification algorithm used to define the classes and subclasses of LN diagnosis.

The degree of activity and chronicity in SLE must be refined through a much more precise correspondence between the score value and the limitation or extension of corpuscular and interstitial lesions. Rapid on-site examination ROSE is a rapid, real-time examination method. The aim of our study is to evaluate the impact of ROSE on adequate specimen sampling, rapid results and high diagnostic rate.

We evaluated the diagnostic capacity of ROSE for malignant tumors, by considering the histopathological examination as the diagnostic gold standard.

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In our retrospective and descriptive study, we analyze the data of EBUS-TBNA examinations with ROSE and histopathological exam, performed for diagnostic purposes for hilar and mediastinal adenopathies of unknown origin. The age of the patients varied from 21 to 80 years, with an average age of There were 98 male patients, representing The sensitivity of the ROSE is This brings a valuable contribution to the improvement of lung cancer diagnostic.

The present paper aimed to define the profile of SCC of the lip with major risk factors. The study included 20 selected cases diagnosed with lower lip SCC, using a webber fat burner 66 volum of antibodies which addressed cell proliferation Ki67perturbation of the cell cycle p53angiogenesis VEGF - vascular endothelial growth factorfactors related to tumor cell interaction with the extracellular matrix CD Ki67 immunoexpression was identified in all the cases.

We found significantly higher mean values of Ki67 PI in pT3 lesion, compared with pT2 and pT lesions, and with no statistically significant differences in lip SCC with associated lymph node metastasis pN1compared to those with no lymph node metastasis pN0.

Immunohistochemical investigations in lip SCC, regarding the expression of p53, Ki67, CD44 and VEGF, revealed results that suggest their ability to assess the prognosis and progression of tumor evolution.

Optical coherence tomography applications in tooth wear diagnosis Veronica Mercut, Sanda Mihaela Popescu, Monica Scrieciu, Marina Olimpia Amarascu, Mihaela Vatu, Oana Andreea Diaconu, Eugen Osiac, Stefan Mugurel Ghelase Dental wear represents an irreversible loss of dental hard tissue under the action of physical, chemical and mechanical factors, excluding dental caries and acute trauma.

Four clinical forms of dental wear are described: erosion, attrition, abfraction, and abrasion. Most experts agree that in each clinical form multiple etiological factors are involved, one being predominant.

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Optical coherence tomography OCT is a non-invasive optical method characterized by a micronic resolution. The applications of this type of investigation are multiple in the medical field in recent years, and OCT is gaining a growing importance in dentistry.

The study pointed out through OCT imaging for the erosive tooth wear lesion the existence of chemical aggression, with strong demineralization of enamel and dentin. For attrition lesion, OCT images showed the contribution of excessive force and friction movements specific to bruxism. In abfraction, OCT image revealed the importance of the mechanic factor in producing this form of tooth wear and abrasion damage studied may be considered physiological, according to patient age. OCT examination may reveal existing lesions in hard dental tissues for each clinical form and could bring evidence on the mechanisms involved.

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Steatosis may be an important cofactor in both accelerating fibrosis and increasing liver necroinflammatory activity in chronic hepatitis C. The main objective of this study was the evaluation of biological response rates, early viral response, sustained viral response in patients with chronic hepatitis C treated with Interferon-alpha IFN-alphaPegylated PEG -IFN-alpha2a or -alpha2b plus Ribavirin and to relate it to the presence of hepatic steatosis.

There were selected to take part to the research patients with chronic hepatitis C who have fulfilled all inclusion and exclusion criteria and were treated with PEG-IFN plus Ribavirin.

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Steatosis was graded using the Brunt system. These parameters were included in an area under curve AUC analysis. Purpose is to estimate their degree of influence on getting early viral response EVR and sustained viral response SVR. Based on the obtained results, it appears that initial value of HCV-RNA, dVL parameter value low relative percentage of viral load during the first 12 weeks of treatmenthistological scores steatosis may be predictive in the viral response in chronic hepatitis C.

A novel method for measuring subcutaneous adipose tissue using ultrasound in children - interobserver consistency Adela Chirita-Emandi, Maria Camelia Papa, Liliana Abrudan, Mihaela Amelia Dobrescu, Maria Puiu, Iulian Puiu Velea, Corina Paul Background: Currently, sufficiently accurate field methods for body composition assessment in children are missing. The ultrasound method for assessing adipose tissue thickness has been used extensively in sport medicine.

However, there are no studies looking at the reliability of this method in non-athletic children. This paper aims to determine the inter-observer reliability in measuring the uncompressed subcutaneous adipose tissue thickness using ultrasound, in children.

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Subjects, Materials and Methods: Forty healthy children 20 males, 20 femalesmedian age Three observers used a Hosand BX Ultrasonic Adipometer to measure uncompressed subcutaneous adipose tissue thickness at three sites: triceps, subscapular, supraspinale.

A single experienced observer used the three sites to also measure the compressed adipose thickness using a skinfold caliper. Results: Individual observer deviations from the mean webber fat burner 66 volum of the three observers in adipometer measurement had a standard deviation of 1. Conclusions: This novel ultrasound measurement technique can be used with good accuracy and reliability to measure uncompressed subcutaneous adipose tissue thickness in children, sustaining its application for research and clinical purposes, however larger studies are needed.

A total of patients with gastric adenocarcinoma and healthy controls were included in this study. Also, we compared allele frequencies and no correlation was found OR 0. The sub-classification of gastric cancer into non-cardia and cardia or intestinal and diffuse type did not reveal any statistically significant difference for investigated polymorphism.

Radiological and optical coherence tomography aspects in external root resorption Sanda Mihaela Popescu, Veronica Mercut, Monica Scrieciu, Razvan Mercut, Florin Dan Popescu, Adina Monica Chiriac, Webber fat burner 66 volum Mihaela Craitoiu, Eugen Osiac Pathological external root resorption is a process by which the hard tooth substance is lost because of action of different local irritative or systemic factors.

Six forms of webber fat burner 66 volum root resorption are described: surface external root resorption, inflammatory external root resorption, replacement external root resorption, invasive external cervical root resorption, ankylosis and transient apical breakdown. The objective of the study was to establish the prevalence of the pathological root resorption in a retrospective radiological study, to highlight radiological aspects of external root resorption and to describe optical coherence tomography OCT aspects in pathological root resorption.

Radiological exam was very useful to detect the form of root resorption but also to establish possible etiological factors. The study presents the radiological aspects of some forms of pathological external root resorption highlighted on radiography accompanied by radiolucency of the adjacent bone to resorption lesion as in inflammatory external root resorption and in invasive cervical root resorption or as changes of the root form, in which the missing part of the root is replaced by the bone tissue, without radiolucency as in replacement root resorption.

The comparison of the OCT aspects of the cele mai bune aplicații de înregistrare în greutate root resorption in primary teeth with the OCT aspects of pathological root resorption in permanent teeth showed an obvious difference between the images of the OCT signal of the two types of resorption.

The OCT signal from the cement is stronger in pathological root resorption, and the OCT signal from the dentin in teeth with inflammatory external root resorption showed a demineralized dentin with multiple heterogeneities, anfractuosities corresponding to resorption craters, with craze lines in subjacent layers of dentin.

Immunohistochemical expression of Ki and p53 along with their digitalized evaluation in the discriminatory analysis of reactive atypia and dysplastic lesions in gastrointestinal biopsies of the stomach Dan Stefan Sampalean, Mihai Turcu, Annamaria Fetyko, Jeno Robert Bartha, Simona Maria Bataga, Sabin Gligore Turdean The differential diagnosis between reactive atypia and non-invasive neoplasia or dysplasia can be challenging webber fat burner 66 volum the case of small conventional forceps biopsy specimens of the stomach.

Writer, Poet, Professor, Literary Critic, Politician Profession Historian, Philosopher Signature In parallel with his scientific contributions, Nicolae Iorga was a prominent right-of-centre activist, whose political theory bridged conservatismRomanian nationalismand agrarianism. From Marxist beginnings, he switched sides and became a maverick disciple of the Junimea movement. Iorga later became a leadership figure at Sămănătorulthe influential literary magazine with populist leanings, and militated within the Cultural League for the Unity of All Romanians, founding vocally conservative publications such as Neamul Românesc, Drum Drept, Cuget Clar and Floarea Darurilor. His support for the cause of ethnic Romanians in Austria-Hungary made him a prominent figure in the pro- Entente camp by the time of World War I, and ensured him a special political role during the interwar existence of Greater Romania.

Despite the existence of several classifications for neoplastic epithelial lesions of the stomach, there are few auxiliary tools for aiding in this decision besides standard stains. We studied the utility of Ki and p53 immunohistochemistry in this setting and their clinico-pathological correlations, based on a set of 99 cases with cytological or architectural atypia reviewed by three pathologists.

We also tested a digitalized method based on the ImageJ software for the evaluation of Ki expression to determine whether this could be of an additional help. Conclusions: Ki and p53 expression correlates well with microscopic and morphological modifications in biopsies and can be a useful tool in confirming or dismissing an impression of dysplasia in routine pathological work-up.

Digital processing is cumbersome and of limited value and it could only be of additional help if more automated methods are developed. According to the literature, there are many studies on the immunohistochemical aspects of the myoepithelial cells, present in the pleomorphic adenoma of the salivary gland. A big diversity of mono and polyclonal antibodies, such as the cytokeratins, muscular proteins and other markers, has been used.